Administration of Extended Release (ER) Buprenorphine

ERIK, Office of the Attending Veterinarian Guideline, Revised 07/2025

Buprenorphine ER-LAB (Bup ER) is an extended-release analgesic compounded by Wedgewood that lasts ~48 hours in mice and rats. Only ULAR staff can administer Bup ER for researchers when it is listed on their IACUC protocol. Another extended-release buprenorphine formulation, Ethiqa XR®, is available for purchase and administration directly by investigative staff holding a controlled drug license.

Bup ER injection requests are scheduled between 8:00 a.m. and 3:30 p.m., Monday through Friday. Injections outside these hours and on university holidays incur additional costs and typically cannot be accommodated due to limited personnel. All requests are scheduled on a first-come, first-served basis and are subject to staffing availability. Requests should be submitted at least 3 business days prior to the requested injection date. Upon receipt of your request, a member of the medicine team will confirm your requested time is available via email.

Bup ER is charged as the cost of the drug for each animal plus technical time for administration of the request (charged in 15-minute increments). Drug costs are subject to change. View current rates for technical time.

Laboratory Animal Pricing Schedule
Species Weight Cost
Mouse 15-30g $2.00 per mouse + technical time
Rat <125g $4.00 per rat + technical time
Rat 126-205g $8.00 per rat + technical time
Rat 206-290g $12.00 per rat + technical time
Rat 291-375g $16.00 per rat + technical time
Rat 376-455g $20.00 per rat + technical time
Rat 456-540g $24.00 per rat + technical time
Rat 541-625g $28.00 per rat + technical time
Rat 626-710g $32.00 per rat + technical time
Rat 711-795g $36.00 per rat + technical time
Rat 796-880g $40.00 per rat + technical time

Request Process

  1. Complete the Buprenorphine ER Injection Request form.
  2. Look for a confirmation email from the ULAR medicine team.
  3. Identify cages with a blue surgery card prior to injection.
  4. Email cage locations and rat weights (if applicable) to OR-ULARERBup@osu.edu if not already provided.

Article ID: 103
Created: July 23, 2025
Last Updated: July 23, 2025

Online URL: https://ohiostateresearch.knowledgebase.co/article/administration-of-extended-release-40;er-41;-buprenorphine-103.html